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Campo DC | Valor | Idioma |
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dc.contributor.author | Ferreira, Chrystiano de C. | en_US |
dc.contributor.author | Dufloth, Rozany | en_US |
dc.contributor.author | Carvalho, Ana C. de | en_US |
dc.contributor.author | Reis, Rui M. | en_US |
dc.contributor.author | Santana, Iara | en_US |
dc.contributor.author | Carvalho, Raiany S. | en_US |
dc.contributor.author | Gama, Ricardo R. | en_US |
dc.date.accessioned | 2024-09-23T18:25:20Z | - |
dc.date.available | 2024-09-23T18:25:20Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Ferreira, Chrystiano de C., et al. “Correlation of P16 immunohistochemistry with clinical and epidemiological features in oropharyngeal squamous-cell carcinoma”. PLOS ONE, vol. 16, no 6, junho de 2021, p. e0253418. DOI.org (Crossref), https://doi.org/10.1371/journal.pone.0253418. | en_US |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://repo.saocamilo-sp.br:8080/jspui/handle/123456789/2111 | - |
dc.description.abstract | Background: Oropharyngeal cancer is an important public health problem. The aim of our study was to correlatep16 immunohistochemistry in oropharynx squamous cell carcinomas(OPSCC) with clinical and epidemiological features. Material and methods: We conducted across-sectional study on patients with OPSCC treated at a single institution from 2014 to 2019. Epidemiological and clinical-pathological data were collected from medical records and a questionnaire was applied to determine alcohol consumption, smoking, and sexual behavior. The HPV status was determined by p16 immunohistochemistry. Results: A total of 252 patients participated in the study, of these 221 (87.7%) were male. There were 81 (32.14%) p16 positive cases and 171 (67.85%) p16 negative cases. The p16positive group was significantly associated with younger patients (50-59 years), higher education level, lower clinical stage and patients who never drank or smoked. Through univariate logistic regression, we observed that female sex (OR, 3.47; 95% CI, 1.60-7.51) and higher education level (OR, 9.39; 95% CI, 2, 81-31,38) were significantly more likely to be p16 positive. Early clinical stage (AJCC8ed) was more associated with p16 positivity both in univariate (OR, 0.14; 95% CI, 0.07-0.26, p<0.001) and multivariate analysis (OR, 0.18; 95% CI, 0.06-0.49, p = 0.001). Conclusion: This study showed that drinkers and current smokers were less likely to be p16+. Female sex, higher education level and younger age at diagnosis were associated with a higher probability of being p16+. Additionally, there was a higher proportion of patients with early clinical stage (I or II) in the p16 positive group when compared to the p16 negative group. | - |
dc.publisher | Public Library of Science | en_US |
dc.relation.ispartof | Plos one, v. 16, n. 6, 2021 | en_US |
dc.subject | Adulto | en_US |
dc.subject | Imuno-histoquímica | en_US |
dc.subject | Estadiamento de neoplasias | en_US |
dc.subject | Comportamento sexual | en_US |
dc.subject | Orofaringe - patologia | en_US |
dc.subject | Carcinoma de células escamosas de cabeça e pescoço | en_US |
dc.title | Correlation of p16 immunohistochemistry with clinical and epidemiological features in oropharyngeal squamous-cell carcinoma | en_US |
dc.type | Artigo de Periódico | en_US |
dc.identifier.doi | 10.1371/journal.pone.0253418 | - |
Aparece nas coleções: | Artigos de Periódicos |
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