Influence of magnitude of weight loss on Adipo/lep ratio in adolescents with obesity undergoing multicomponent therapy

Abstract

Background and aims: The expansion of adipose tissue increases leptin secretion associated with a reduction of adiponectin concentration, which negatively affects health of adolescents with obesity. This study aims to in vestigate the effects of non-intensive interdisciplinary therapy on cardiometabolic parameters including leptin,adiponectin and adiponectin/leptin ratio as a dependent manner on its magnitude of weight loss reduction.Methods and results: Thirty-eight adolescents (14–19 y.o) were enrolled in an interdisciplinary therapy for 20 weeks. Body composition, biochemical parameters, leptin and adiponectin were measured at baseline and after therapy. The adolescents were divided into two groups according to the magnitude of total weight loss, less than 5% (< 5%-n = 18) or greater than or equal to 5% (≥5%-n = 20). Leptin decreased in whole group after therapy, while adiponectin, and adiponectin/leptin ratio increased. Additionally, body composition was im proved. Only the group who lost ≥5% of body weight could reduce the inflammatory state. Conclusion: The interdisciplinary therapy contributes to improve cardiometabolic parameters that could be in volved on inflammation in adolescents with obesity, this improvement occurred mainly when the weight loss is ≥5% of body weight. It could be a target for control the inflammatory process related to obesity in adolescents