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dc.contributor.authorPacheco, Rafael Leiteen_US
dc.contributor.authorRiera, Rachelen_US
dc.date.accessioned2024-03-26T11:43:16Z-
dc.date.available2024-03-26T11:43:16Z-
dc.date.issued2020-
dc.identifier.citationPacheco, Rafael Leite ; Riera, Rachel. “Hydroxychloroquine and chloroquine for COVID-19 infection. Rapid systematic review”. Journal of Evidence-Based Healthcare, vol. 2, no 1, março de 2020, p. 74–92. DOI.org (Crossref), https://doi.org/10.17267/2675-021Xevidence.v2i1.2843.en_US
dc.identifier.issn2675-021X-
dc.identifier.urihttp://repo.saocamilo-sp.br:8080/jspui/handle/123456789/1675-
dc.publisherJournals Bahiana School of Médicine and Public Healthen_US
dc.relation.ispartofJournal of evidence-based healthcare, v. 2, n. 1, p. 74-92, 2020en_US
dc.subjectCovid-19en_US
dc.subjectSARS-CoV-2en_US
dc.subjectCoronavirusen_US
dc.subjectHidroxicloroquinaen_US
dc.subjectCloroquinaen_US
dc.subjectRevisão sistemáticaen_US
dc.titleHydroxychloroquine and chloroquine for COVID-19 infection. Rapid systematic reviewen_US
dc.typeArtigo de Periódicoen_US
dcterms.abstractCONTEXT: Based on the results of preliminary studies, the off-label use of hydroxychloroquine for COVID-19 infection has been observed in practice. OBJECTIVES: To identify, systematically assess and summarize the best available evidence on the efficacy and safety of the use of hydroxychloroquine and chloroquine for COVID-19 infection. METHODS: Rapid systematic review. RESULTS: After the selection process, 30 studies were included: one open-label randomized trial, one open-label non-randomized trial and 28 ongoing studies. The outcome 'detection of viral load in oral swab' (surrogate outcome) was evaluated by both studies, involving a total of 72 participants. The findings of the studies were discordant: one study observed a higher frequency of negative viral load associated with hydroxychloroquine on day-7, while the other study did not observe any difference between hydroxychloroquine and the control group (standard treatment) on day-6. Both studies have methodological limitations when evaluated by specific tools according to study design (Cochrane Bias Risk Table and ROBINS-I). CONCLUSION: This rapid systematic review identified two clinical studies (with available data), with limited methodological quality, that evaluated the effects of hydroxychloroquine for COVID-19 infection. Based on the findings of these two studies, the efficacy and safety of hydroxychloroquine and chloroquine in patients with COVID-19 is still uncertain (very low evidence certainty) and its routine use for this situation should not be recommended until the results of ongoing studies could provide a proper assessment of their effects.-
dc.identifier.doi10.17267/2675-021Xevidence.v2i1.2843-
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