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Título: | Changes in lipoproteins associated with lipid-lowering and antiplatelet strategies in patients with acute myocardial infarction |
Autor(es): | Lotfollahi, Zahra Mello, Ana P. Q. Fonseca, Francisco A. H. Machado, Luciene O. Mathias, Andressa F. Izar, Maria C. Damasceno, Nagila R. T. Oliveira, Cristiano L. P. F. Neto, Antônio M. |
Palavras-chave: | Anticolesterolemiantes Inibidores de hidroximetilglutaril-CoA redutases Infarto do miocárdio Clopidogrel Ezetimiba Lipoproteínas |
Data do documento: | 2022 |
Editor: | Public Library of Science |
Citação: | Lotfollahi, Zahra, et al. “Changes in Lipoproteins Associated with Lipid-Lowering and Antiplatelet Strategies in Patients with Acute Myocardial Infarction”. PLOS ONE, organizado por Salvatore De Rosa, vol. 17, no 8, agosto de 2022, p. e0273292. DOI.org (Crossref), https://doi.org/10.1371/journal.pone.0273292. |
Resumo: | BACKGROUND:Despite lipid-lowering and antiplatelet therapy, the pattern of residual lipoproteins seems relevant to long-term cardiovascular outcomes. This study aims to evaluate the effects of combined therapies, commonly used in subjects with acute myocardial infarction, in the quality of low-density lipoprotein (LDL) particles. METHODS:Prospective, open-label trial, included patients with acute myocardial infarction. Patients were randomized to antiplatelet treatment (ticagrelor or clopidogrel) and subsequently to lipid-lowering therapy (rosuvastatin or simvastatin/ezetimibe) and were followed up for six months. Nonlinear optical properties of LDL samples were examined by Gaussian laser beam (Z-scan) to verify the oxidative state of these lipoproteins, small angle X-ray scattering (SAXS) to analyze structural changes on these particles, dynamic light scattering (DLS) to estimate the particle size distribution, ultra violet (UV)-visible spectroscopy to evaluate the absorbance at wavelength 484 nm (typical from carotenoids), and polyacrylamide gel electrophoresis (Lipoprint) to analyze the LDL subfractions.RESULTS: Simvastatin/ezetimibe with either clopidogrel or ticagrelor was associated with less oxidized LDL, and simvastatin/ezetimibe with ticagrelor to lower cholesterol content in the atherogenic subfractions of LDL, while rosuvastatin with ticagrelor was the only combination associated with increase in LDL size. CONCLUSIONS: The quality of LDL particles was influenced by the antiplatelet/lipid-lowering strategy, with ticagrelor being associated with the best performance with both lipid-lowering therapies. Trial registration NCT02428374. |
URI: | http://repo.saocamilo-sp.br:8080/jspui/handle/123456789/1614 |
ISSN: | 1932-6203 |
Aparece nas coleções: | Artigos de Periódicos |
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Ana Paula de Queiroz Melo - Changes in lipoproteins associated with.pdf | 2.45 MB | Adobe PDF | Visualizar/Abrir |
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